:root {
  --paper: #f5f2eb;
  --paper-deep: #e8e3d7;
  --card: rgba(255, 255, 255, 0.82);
  --card-strong: rgba(255, 255, 255, 0.92);
  --ink: #15313c;
  --ink-soft: #3a5663;
  --line: rgba(21, 49, 60, 0.1);
  --brand: #185c73;
  --brand-soft: #4a8fa6;
  --accent: #e7a03a;
  --mint: #9fd7c1;
  --shadow: 0 24px 60px rgba(16, 36, 62, 0.12);
  --radius-xl: 28px;
  --radius-lg: 20px;
  --radius-md: 14px;
  --grd: #d6b05e;
  --egf: #78c6d8;
  --tnf: #df8a71;
  --pole: #f0d99a;
  --pxl: #cb7aa0;
  --tm: #8f90ef;
  --kinase: #185c73;
  --cdx123: #ff5f6d;
  --fab125: #f3b15b;
  --cdx125: #f18d27;
  --ligand: #2f3137;
  --ligand-soft: #a0a5ae;
  --membrane: #d7d25d;
  --contact: #4f6a79;
}

* {
  box-sizing: border-box;
}

html,
body {
  min-height: 100%;
}

body {
  margin: 0;
  padding: 24px;
  color: var(--ink);
  background:
    radial-gradient(circle at 12% 18%, rgba(159, 215, 193, 0.34), transparent 38%),
    radial-gradient(circle at 85% 5%, rgba(231, 160, 58, 0.2), transparent 35%),
    linear-gradient(160deg, #fcfbf8 0%, var(--paper) 72%);
  font-family: "Space Grotesk", "Avenir Next", "Segoe UI", sans-serif;
}

body::before {
  content: "";
  position: fixed;
  inset: 0;
  pointer-events: none;
  background-image:
    linear-gradient(rgba(21, 49, 60, 0.03) 1px, transparent 1px),
    linear-gradient(90deg, rgba(21, 49, 60, 0.03) 1px, transparent 1px);
  background-size: 44px 44px;
  mask-image: linear-gradient(180deg, rgba(0, 0, 0, 0.58), transparent 96%);
}

.shell {
  position: relative;
  z-index: 1;
  width: min(1280px, 100%);
  margin: 0 auto;
  display: grid;
  gap: 22px;
}

.intro,
.viewer-panel,
.status-card,
.note-card {
  border: 1px solid var(--line);
  border-radius: var(--radius-xl);
  background: var(--card);
  backdrop-filter: blur(14px);
  box-shadow: var(--shadow);
}

.intro {
  position: relative;
  overflow: hidden;
  padding: clamp(1.35rem, 2.8vw, 2.3rem);
  background:
    linear-gradient(120deg, rgba(255, 255, 255, 0.82), rgba(255, 255, 255, 0.92)),
    linear-gradient(135deg, rgba(74, 143, 166, 0.08), rgba(231, 160, 58, 0.08));
}

.intro::after {
  content: "";
  position: absolute;
  inset: auto -4rem -5rem auto;
  width: 14rem;
  height: 14rem;
  border-radius: 50%;
  background: radial-gradient(circle, rgba(231, 160, 58, 0.2), rgba(231, 160, 58, 0));
  pointer-events: none;
}

.intro-copy,
.viewer-panel,
.note-card {
  position: relative;
  z-index: 1;
}

.viewer-panel,
.note-card {
  padding: 24px;
}

.eyebrow,
.status-label {
  margin: 0 0 0.6rem;
  text-transform: uppercase;
  letter-spacing: 0.14em;
  font-weight: 700;
  font-size: 0.74rem;
}

.eyebrow,
.toolbar-label,
.status-label {
  color: var(--brand);
}

h1,
h2 {
  margin: 0;
  font-family: "Fraunces", "Times New Roman", serif;
  letter-spacing: -0.02em;
  line-height: 1.05;
}

h1 {
  max-width: 12ch;
  font-size: clamp(2.4rem, 5vw, 4.2rem);
}

h2 {
  font-size: 1.45rem;
}

.intro-body,
.caption p,
.note-card p {
  margin: 1rem 0 0;
  color: var(--ink-soft);
  line-height: 1.65;
}

.intro-copy {
  max-width: 76ch;
}

.hero-actions {
  display: flex;
  gap: 12px;
  flex-wrap: wrap;
  margin-top: 1.2rem;
}

.hero-link,
.antibody-button,
.state-button,
.secondary-button {
  appearance: none;
  border: 0;
  cursor: pointer;
  font: inherit;
  transition:
    transform 160ms ease,
    box-shadow 160ms ease,
    background 160ms ease,
    color 160ms ease;
}

.hero-link {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  padding: 12px 18px;
  border-radius: 999px;
  background: rgba(21, 49, 60, 0.08);
  color: var(--ink);
  text-decoration: none;
  font-weight: 700;
}

.hero-link:hover,
.antibody-button:hover,
.state-button:hover,
.secondary-button:hover {
  transform: translateY(-1px);
}

.hero-link-primary,
.state-button.is-active {
  background: var(--brand);
  color: #fff;
  box-shadow: 0 12px 24px rgba(24, 92, 115, 0.22);
}

.toolbar {
  display: flex;
  align-items: flex-end;
  justify-content: space-between;
  gap: 16px;
  flex-wrap: wrap;
}

.toolbar-label {
  display: block;
  margin: 0 0 10px;
  font-size: 0.74rem;
  font-weight: 700;
  letter-spacing: 0.14em;
  text-transform: uppercase;
}

.antibody-toolbar {
  margin-top: 16px;
  padding: 16px 18px;
  border-radius: 18px;
  background: rgba(255, 255, 255, 0.62);
  border: 1px solid rgba(21, 49, 60, 0.08);
}

.button-row {
  display: flex;
  gap: 10px;
  flex-wrap: wrap;
}

.antibody-button,
.state-button,
.secondary-button {
  padding: 12px 16px;
  border-radius: 999px;
}

.antibody-button,
.state-button {
  background: rgba(255, 255, 255, 0.76);
  color: var(--ink-soft);
  box-shadow: inset 0 0 0 1px rgba(21, 49, 60, 0.08);
}

.antibody-button.is-active {
  background: var(--brand);
  color: #fff;
  box-shadow: 0 12px 24px rgba(24, 92, 115, 0.22);
}

.antibody-button.is-active[data-antibody="cdx123"] {
  background: var(--cdx123);
  box-shadow: 0 12px 24px rgba(255, 95, 109, 0.26);
}

.antibody-button.is-active[data-antibody="fab125"] {
  background: var(--fab125);
  box-shadow: 0 12px 24px rgba(243, 177, 91, 0.28);
}

.antibody-button.is-active[data-antibody="cdx125"] {
  background: var(--cdx125);
  box-shadow: 0 12px 24px rgba(241, 141, 39, 0.28);
}

.antibody-button:disabled {
  cursor: default;
  opacity: 0.48;
  transform: none;
}

.secondary-button {
  background: rgba(21, 49, 60, 0.08);
  color: var(--ink);
  font-weight: 700;
}

.canvas-wrap {
  position: relative;
  overflow: hidden;
  margin-top: 20px;
  min-height: 540px;
  border-radius: 24px;
  border: 1px solid rgba(255, 255, 255, 0.45);
  background:
    radial-gradient(circle at 18% 14%, rgba(159, 215, 193, 0.26), transparent 20%),
    radial-gradient(circle at 84% 12%, rgba(231, 160, 58, 0.18), transparent 24%),
    linear-gradient(180deg, rgba(255, 255, 255, 0.56), rgba(230, 233, 238, 0.48));
}

.state-badge {
  position: absolute;
  top: 18px;
  left: 18px;
  z-index: 2;
  min-width: 160px;
  padding: 11px 14px 12px;
  border-radius: 18px;
  border: 1px solid transparent;
  backdrop-filter: blur(10px);
  box-shadow: 0 14px 34px rgba(16, 36, 62, 0.14);
  pointer-events: none;
}

.state-badge--inactive {
  background: rgba(216, 79, 95, 0.14);
  border-color: rgba(216, 79, 95, 0.24);
  color: #8b1c2a;
}

.state-badge--primed {
  background: rgba(231, 160, 58, 0.16);
  border-color: rgba(231, 160, 58, 0.26);
  color: #93530b;
}

.state-badge--active {
  background: rgba(72, 212, 106, 0.14);
  border-color: rgba(72, 212, 106, 0.24);
  color: #146b2a;
}

.state-badge-status,
.state-badge-label {
  display: block;
}

.state-badge-status {
  text-transform: uppercase;
  letter-spacing: 0.12em;
  font-size: 0.72rem;
  font-weight: 700;
  opacity: 0.88;
}

.state-badge-label {
  margin-top: 2px;
  font-size: 1rem;
  line-height: 1.1;
}

#scene {
  display: block;
  width: 100%;
  height: 540px;
}

.hint {
  position: absolute;
  right: 18px;
  bottom: 16px;
  padding: 8px 12px;
  border-radius: 999px;
  background: rgba(255, 255, 255, 0.82);
  color: var(--ink-soft);
  font-size: 0.88rem;
  border: 1px solid rgba(21, 49, 60, 0.08);
}

.caption {
  margin-top: 20px;
}

.status-grid,
.notes {
  display: grid;
  gap: 16px;
}

.status-grid {
  grid-template-columns: repeat(4, minmax(0, 1fr));
}

.status-card {
  padding: 18px 20px;
}

.status-card strong {
  font-family: "Fraunces", "Times New Roman", serif;
  font-size: 1.45rem;
}

.notes {
  grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
}

.note-card {
  background: var(--card-strong);
}

.note-card a {
  color: var(--brand);
  text-decoration-thickness: 1px;
}

@media (max-width: 980px) {
  body {
    padding: 16px;
  }

  .intro,
  .status-grid,
  .notes {
    grid-template-columns: 1fr;
  }

  .canvas-wrap,
  #scene {
    min-height: 440px;
    height: 440px;
  }
}